A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein

Asparaginyl endopeptidases (AEPs) are a class of enzymes commonly associated with proteolysis in the maturation of seed storage proteins. However, a subset of AEPs work preferentially as peptide ligases, coupling release of a leaving group to formation of a new peptide bond. These “ligase-type” AEPs...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Harris, Karen S., Guarino, Rosemary F., Dissanayake, Ravindu S., Quimbar, Pedro, McCorkelle, Owen C., Poon, Simon, Kaas, Quentin, Durek, Thomas, Gilding, Edward K., Jackson, Mark A., Craik, David J., van der Weerden, Nicole L., Anders, Robin F., Anderson, Marilyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658665/
https://ncbi.nlm.nih.gov/pubmed/31346249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47273-7
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