Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

Cyclotides are diverse plant backbone cyclized peptides that have attracted interest as pharmaceutical scaffolds, but fundamentals of their biosynthetic origin remain elusive. Backbone cyclization is a key enzyme-mediated step of cyclotide biosynthesis and confers a measure of stability on the resul...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Harris, Karen S., Durek, Thomas, Kaas, Quentin, Poth, Aaron G., Gilding, Edward K., Conlan, Brendon F., Saska, Ivana, Daly, Norelle L., van der Weerden, Nicole L., Craik, David J., Anderson, Marilyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703859/
https://ncbi.nlm.nih.gov/pubmed/26680698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10199
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