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Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

Cyclotides are diverse plant backbone cyclized peptides that have attracted interest as pharmaceutical scaffolds, but fundamentals of their biosynthetic origin remain elusive. Backbone cyclization is a key enzyme-mediated step of cyclotide biosynthesis and confers a measure of stability on the resul...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Harris, Karen S., Durek, Thomas, Kaas, Quentin, Poth, Aaron G., Gilding, Edward K., Conlan, Brendon F., Saska, Ivana, Daly, Norelle L., van der Weerden, Nicole L., Craik, David J., Anderson, Marilyn A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703859/
https://ncbi.nlm.nih.gov/pubmed/26680698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10199
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