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Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase
Cyclotides are diverse plant backbone cyclized peptides that have attracted interest as pharmaceutical scaffolds, but fundamentals of their biosynthetic origin remain elusive. Backbone cyclization is a key enzyme-mediated step of cyclotide biosynthesis and confers a measure of stability on the resul...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4703859/ https://ncbi.nlm.nih.gov/pubmed/26680698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10199 |
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