Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model

BACKGROUND: Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standard 1:1 ratio on transfusion requirements, correction of TIC, and organ damage i...

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Veröffentlicht in:Intensive Care Med Exp
Hauptverfasser: Kleinveld, Derek J. B., Wirtz, Mathijs R., van den Brink, Daan P., Maas, M. Adrie W., Roelofs, Joris J. T. H., Goslings, J. Carel, Hollmann, Markus W., Juffermans, Nicole P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658636/
https://ncbi.nlm.nih.gov/pubmed/31346913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-019-0242-5
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