Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors

The attachment of myristate to the N-terminal glycine of certain proteins is largely a co-translational modification catalyzed by N-myristoyltransferase (NMT), and involved in protein membrane-localization. Pathogen NMT is a validated therapeutic target in numerous infectious diseases including mala...

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Udgivet i:Cell Chem Biol
Main Authors: Schlott, Anja C., Mayclin, Stephen, Reers, Alexandra R., Coburn-Flynn, Olivia, Bell, Andrew S., Green, Judith, Knuepfer, Ellen, Charter, David, Bonnert, Roger, Campo, Brice, Burrows, Jeremy, Lyons-Abbott, Sally, Staker, Bart L., Chung, Chun-Wa, Myler, Peter J., Fidock, David A., Tate, Edward W., Holder, Anthony A.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658617/
https://ncbi.nlm.nih.gov/pubmed/31080074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.03.015
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