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IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
Activation of macrophage proinflammatory and antimicrobial phenotypes is regulated by IFN-γ and LPS via synergistic induction of canonical, inflammatory NF-κB target genes. However, whether IFN-γ negatively regulates components of the LPS response, and how this may affect macrophage activation, is s...
Uloženo v:
| Vydáno v: | Nat Commun |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6658531/ https://ncbi.nlm.nih.gov/pubmed/31346169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11147-3 |
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