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From the Broad Phase II Trial to Precision Oncology: A Perspective on the Origins of Basket and Umbrella Clinical Trial Designs in Cancer Drug Development

Oncologic phase II trials that evaluate the activity of new therapeutic agents have evolved dramatically over the past 50 years. The standard approach beginning in the late 1960’s focused on individual studies that evaluated new anticancer agents against a wide range of both solid and hematopoietic...

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Podrobná bibliografie
Vydáno v:Cancer J
Hlavní autoři: Doroshow, Deborah B., Doroshow, James H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658138/
https://ncbi.nlm.nih.gov/pubmed/31335388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PPO.0000000000000386
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