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Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals
A tiered bioassay and data analysis scheme is described for elucidating the most common molecular targets responsible for chemical-induced in vitro aneugenicity: tubulin destabilization, tubulin stabilization, and inhibition of mitotic kinase(s). To evaluate this strategy, TK6 cells were first expos...
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| Publicado en: | Toxicol Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6657583/ https://ncbi.nlm.nih.gov/pubmed/31132080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz123 |
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