Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals

A tiered bioassay and data analysis scheme is described for elucidating the most common molecular targets responsible for chemical-induced in vitro aneugenicity: tubulin destabilization, tubulin stabilization, and inhibition of mitotic kinase(s). To evaluate this strategy, TK6 cells were first expos...

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Vydáno v:Toxicol Sci
Hlavní autoři: Bernacki, Derek T, Bryce, Steven M, Bemis, Jeffrey C, Dertinger, Stephen D
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Emerging Technologies, Methods, and Models
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657583/
https://ncbi.nlm.nih.gov/pubmed/31132080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz123
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