Cyclophilin D-mediated regulation of the permeability transition pore is altered in mice lacking the mitochondrial calcium uniporter

AIMS: Knockout (KO) of the mitochondrial Ca(2+) uniporter (MCU) in mice abrogates mitochondrial Ca(2+) uptake and permeability transition pore (PTP) opening. However, hearts from global MCU-KO mice are not protected from ischaemic injury. We aimed to investigate whether adaptive alterations occur in...

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Bibliografiska uppgifter
I publikationen:Cardiovasc Res
Huvudupphovsmän: Parks, Randi J, Menazza, Sara, Holmström, Kira M, Amanakis, Georgios, Fergusson, Maria, Ma, Hanley, Aponte, Angel M, Bernardi, Paolo, Finkel, Toren, Murphy, Elizabeth
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657279/
https://ncbi.nlm.nih.gov/pubmed/30165576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy218
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