Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway

Intracellular mislocalization of TAR DNA-binding protein 43 (TDP-43), a nuclear DNA/RNA-binding protein involved in RNA metabolism, is a pathological hallmark of amyotrophic lateral sclerosis (ALS). Although the aggregation-prone, TDP-43 C-terminal domain is widely considered as a key component of T...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Nishino, Kohei, Watanabe, Seiji, Shijie, Jin, Murata, Yuri, Oiwa, Kotaro, Komine, Okiru, Endo, Fumito, Tsuiji, Hitomi, Abe, Manabu, Sakimura, Kenji, Mishra, Amit, Yamanaka, Koji
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657153/
https://ncbi.nlm.nih.gov/pubmed/31345270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0776-5
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