Enterococcus faecalis CRISPR-Cas Is a Robust Barrier to Conjugative Antibiotic Resistance Dissemination in the Murine Intestine

CRISPR-Cas systems are barriers to horizontal gene transfer (HGT) in bacteria. Little is known about CRISPR-Cas interactions with conjugative plasmids, and studies investigating CRISPR-Cas/plasmid interactions in in vivo models relevant to infectious disease are lacking. These are significant gaps i...

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Bibliographic Details
Published in:mSphere
Main Authors: Price, Valerie J., McBride, Sara W., Hullahalli, Karthik, Chatterjee, Anushila, Duerkop, Breck A., Palmer, Kelli L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656873/
https://ncbi.nlm.nih.gov/pubmed/31341074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00464-19
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