E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration

In prior work we demonstrated that loss of E2F transcription factors inhibits metastasis. Here we address the mechanisms for this phenotype and identify the E2F regulated genes that coordinate tumor cell metastasis. Transcriptomic profiling of E2F1 knockout tumors identified a role for E2F1 as a mas...

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Publicado no:Sci Rep
Main Authors: Hollern, Daniel P., Swiatnicki, Matthew R., Rennhack, Jonathan P., Misek, Sean A., Matson, Brooke C., McAuliff, Andrew, Gallo, Kathleen A., Caron, Kathleen M., Andrechek, Eran R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656723/
https://ncbi.nlm.nih.gov/pubmed/31341204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47218-0
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