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The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease

INTRODUCTION: Clinical trials on preclinical Alzheimer’s disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more efficiently than models of time to progression. METHO...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement (N Y)
Main Authors: Li, Dan, Iddi, Samuel, Aisen, Paul S., Thompson, Wesley K., Donohue, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656701/
https://ncbi.nlm.nih.gov/pubmed/31367671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trci.2019.04.004
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