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Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport
The epithelial anion transporter SLC26A9 contributes to airway surface hydration and gastric acid production. Colocalizing with CFTR, SLC26A9 has been proposed as a target for the treatment of cystic fibrosis. To provide molecular details of its transport mechanism, we present cryo-EM structures and...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6656431/ https://ncbi.nlm.nih.gov/pubmed/31339488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46986 |
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