Targeting miR‐193a‐AML1‐ETO‐β‐catenin axis by melatonin suppresses the self‐renewal of leukaemia stem cells in leukaemia with t (8;21) translocation

AML1‐ETO, the most common fusion oncoprotein by t (8;21) in acute myeloid leukaemia (AML), enhances hematopoietic self‐renewal and leukemogenesis. However, currently no specific therapies have been reported for t (8;21) AML patients as AML1‐ETO is still intractable as a pharmacological target. For t...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Zhou, Bin, Ye, Haige, Xing, Chongyun, Liang, Bin, Li, Haiying, Chen, Linling, Huang, Xingzhou, Wu, Yanfei, Gao, Shenmeng
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6653044/
https://ncbi.nlm.nih.gov/pubmed/31119862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14399
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