Development, Characterization, and Standardization of a Nose-Only Inhalation Exposure System for Exposure of Rabbits to Small-Particle Aerosols Containing Francisella tularensis

Inhalation of Francisella tularensis causes pneumonic tularemia in humans, a severe disease with a 30 to 60% mortality rate. The reproducible delivery of aerosolized virulent bacteria in relevant animal models is essential for evaluating medical countermeasures. Here we developed optimized protocols...

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Dettagli Bibliografici
Pubblicato in:Infect Immun
Autori principali: O’Malley, Katherine J., Bowling, Jennifer D., Barry, Eileen M., Hazlett, Karsten R. O., Reed, Douglas S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Bacterial Infections
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652755/
https://ncbi.nlm.nih.gov/pubmed/31085702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00198-19
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