Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease

Death receptor 3 (DR3) is a tumor necrosis factor receptor superfamily member (TNFRSF25), which is minimally expressed on resting conventional T cells (though readily inducible upon cell activation), yet highly expressed on resting FoxP3(+) regulatory T cells (Treg). We recently demonstrated that ac...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Mavers, Melissa, Simonetta, Federico, Nishikii, Hidekazu, Ribado, Jessica V., Maas-Bauer, Kristina, Alvarez, Maite, Hirai, Toshihito, Turkoz, Mustafa, Baker, Jeanette, Negrin, Robert S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652149/
https://ncbi.nlm.nih.gov/pubmed/31379829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01624
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