IL-13 Impairs Tight Junctions in Airway Epithelia

Interleukin-13 (IL-13) drives symptoms in asthma with high levels of T-helper type 2 cells (T(h)2-cells). Since tight junctions (TJ) constitute the epithelial diffusion barrier, we investigated the effect of IL-13 on TJ in human tracheal epithelial cells. We observed that IL-13 increases paracellula...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Schmidt, Hanna, Braubach, Peter, Schilpp, Carolin, Lochbaum, Robin, Neuland, Kathrin, Thompson, Kristin, Jonigk, Danny, Frick, Manfred, Dietl, Paul, Wittekindt, Oliver H.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6651493/
https://ncbi.nlm.nih.gov/pubmed/31262043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20133222
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