IL-13 Impairs Tight Junctions in Airway Epithelia

Interleukin-13 (IL-13) drives symptoms in asthma with high levels of T-helper type 2 cells (T<sub>h</sub>2-cells). Since tight junctions (TJ) constitute the epithelial diffusion barrier, we investigated the effect of IL-13 on TJ in human tracheal epithelial cells. We observed that IL-13...

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Detalhes bibliográficos
Main Authors: Hanna Schmidt, Peter Braubach, Carolin Schilpp, Robin Lochbaum, Kathrin Neuland, Kristin Thompson, Danny Jonigk, Manfred Frick, Paul Dietl, Oliver H. Wittekindt
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-06-01
Colecção:International Journal of Molecular Sciences
Assuntos:
lung
epithelia
interleukin 13
tight junction
UBE2Z
ubiquitin
Acesso em linha:https://www.mdpi.com/1422-0067/20/13/3222
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