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Importance of the Choice of a Recombinant System to Produce Large Amounts of Functional Membrane Protein hERG
Human ether-a-gogo related gene (hERG) product is the membrane potassium channel Kv11.1, which is involved in the electrical activity of the heart. As such, it is a key player in the toxicity of many drug candidates. Therefore, having this protein at hand during earlier stages of drug discovery is i...
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| Publicado no: | Int J Mol Sci |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6651182/ https://ncbi.nlm.nih.gov/pubmed/31261773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20133181 |
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