The pyroptotic cell death effector Gasdermin D is activated by gout-associated uric acid crystals but is dispensable for cell death and IL-1β release

The pyroptotic cell death effector, Gasdermin D (GSDMD), is required for murine models of hereditary inflammasome-driven, interleukin-1β (IL-1β)-dependent, autoinflammatory disease, making it an attractive therapeutic target. However, the importance of GSDMD for more common conditions mediated by pa...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Rashidi, Maryam, Simpson, Daniel S., Hempel, Anne, Frank, Daniel, Petrie, Emma, Vince, Angelina, Feltham, Rebecca, Murphy, Jane, Chatfield, Simon M., Salvesen, Guy S., Murphy, James M., Wicks, Ian P., Vince, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650356/
https://ncbi.nlm.nih.gov/pubmed/31209100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900228
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