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Early phase and adaptive design clinical trials in rheumatoid arthritis: a systematic review of early phase trials

OBJECTIVE: Adaptive designs can enable highly sophisticated and efficient early phase trials, but the clinical inference from these trials is surrounded by complexity, and currently there is a paucity but steadily increasing amount of use of these designs in all fields of medicine. We aim to review...

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Detalhes bibliográficos
Publicado no:Rheumatol Adv Pract
Main Authors: Pickles, Tim, Christensen, Robin, Tam, Lai-Shan, Simon, Lee S, Choy, Ernest H
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6649924/
https://ncbi.nlm.nih.gov/pubmed/31431982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rap/rky045
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