Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription

The contribution of nucleoli to the cellular stress response has been discussed for over a decade. Stress-induced inhibition of RNA polymerase I-dependent transcription is hypothesized as a possible effector program in such a response. In this study, we report a new mechanism by which ribosomal DNA...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Velichko, Artem K, Petrova, Nadezhda V, Luzhin, Artem V, Strelkova, Olga S, Ovsyannikova, Natalia, Kireev, Igor I, Petrova, Natalia V, Razin, Sergey V, Kantidze, Omar L
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Genome Integrity, Repair and Replication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6648358/
https://ncbi.nlm.nih.gov/pubmed/31114877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz436
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