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Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex
Proliferating cell nuclear antigen (PCNA) is a sliding clamp that acts as a central co-ordinator for mismatch repair (MMR) as well as DNA replication. Loss of Elg1, the major subunit of the PCNA unloader complex, causes over-accumulation of PCNA on DNA and also increases mutation rate, but it has be...
Gardado en:
| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6648347/ https://ncbi.nlm.nih.gov/pubmed/31114918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz441 |
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