Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIP(s)

BACKGROUND: Vitamin E δ-tocotrienol (VEDT), a vitamin E compound isolated from sources such as palm fruit and annatto beans, has been reported to have cancer chemopreventive and therapeutic effects. METHODS: We report a novel function of VEDT in augmenting tumor necrosis factor-related apoptosis-ind...

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Dettagli Bibliografici
Pubblicato in:Cancer Cell Int
Autori principali: Francois, Rony A., Zhang, Anying, Husain, Kazim, Wang, Chen, Hutchinson, Sean, Kongnyuy, Michael, Batra, Surinder K., Coppola, Domenico, Sebti, Said M., Malafa, Mokenge P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Primary Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6647259/
https://ncbi.nlm.nih.gov/pubmed/31367187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-0876-0
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