Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for (89)Zr-immunoPET

PURPOSE: Currently, the most commonly used chelator for labelling antibodies with (89)Zr for immunoPET is desferrioxamine B (DFO). However, preclinical studies have shown that the limited in vivo stability of the (89)Zr-DFO complex results in release of (89)Zr, which accumulates in mineral bone. Her...

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Foilsithe in:Eur J Nucl Med Mol Imaging
Main Authors: Raavé, René, Sandker, Gerwin, Adumeau, Pierre, Jacobsen, Christian Borch, Mangin, Floriane, Meyer, Michel, Moreau, Mathieu, Bernhard, Claire, Da Costa, Laurène, Dubois, Adrien, Goncalves, Victor, Gustafsson, Magnus, Rijpkema, Mark, Boerman, Otto, Chambron, Jean-Claude, Heskamp, Sandra, Denat, Franck
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer Berlin Heidelberg 2019
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6647232/
https://ncbi.nlm.nih.gov/pubmed/31161258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-019-04343-2
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