Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration of acet...

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Udgivet i:Nat Commun
Main Authors: Antunes, Krist Helen, Fachi, José Luís, de Paula, Rosemeire, da Silva, Emanuelle Fraga, Pral, Laís Passariello, dos Santos, Adara Áurea, Dias, Greicy Brisa Malaquias, Vargas, José Eduardo, Puga, Renato, Mayer, Fabiana Quoos, Maito, Fábio, Zárate-Bladés, Carlos R., Ajami, Nadim J., Sant’Ana, Marcella Ramos, Candreva, Thamiris, Rodrigues, Hosana Gomes, Schmiele, Marcio, Silva Clerici, Maria Teresa Pedrosa, Proença-Modena, José Luiz, Vieira, Angélica Thomas, Mackay, Charles R., Mansur, Daniel, Caballero, Mauricio T., Marzec, Jacqui, Li, Jianying, Wang, Xuting, Bell, Douglas, Polack, Fernando P., Kleeberger, Steven R., Stein, Renato T., Vinolo, Marco Aurélio Ramirez, de Souza, Ana Paula Duarte
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6646332/
https://ncbi.nlm.nih.gov/pubmed/31332169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11152-6
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