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Development of a Suicide Inhibition Based Protein Labeling (SIBLing) Strategy for Nicotinamide N-methyltransferase

Nicotinamide N-methytransferase (NNMT) catalyzes the S-adenosyl-L-methionine (SAM)-dependent methylation of nicotinamide (NAM) to form N-methylnicotinamide (Me-NAM). This enzyme detoxifies xenobiotics and regulates NAD(+) biosynthesis. Additionally, NNMT is overexpressed in various cancers. Herein,...

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Bibliografski detalji
Izdano u:ACS Chem Biol
Glavni autori: Sen, Sudeshna, Mondal, Santanu, Zheng, Li, Salinger, Ari J., Fast, Walter, Weerapana, Eranthie, Thompson, Paul R.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6644700/
https://ncbi.nlm.nih.gov/pubmed/30933557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00211
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