Direct visualization of cardiac transcription factories reveals regulatory principles of nuclear architecture during pathological remodeling

Heart failure is associated with hypertrophying of cardiomyocytes and changes in transcriptional activity. Studies from rapidly dividing cells in culture have suggested that transcription may be compartmentalized into factories within the nucleus, but this phenomenon has not been tested in vivo and...

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Veröffentlicht in:J Mol Cell Cardiol
Hauptverfasser: Karbassi, Elaheh, Rosa-Garrido, Manuel, Chapski, Douglas J., Wu, Yong, Ren, Shuxun, Wang, Yibin, Stefani, Enrico, Vondriska, Thomas M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6644685/
https://ncbi.nlm.nih.gov/pubmed/30742811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.02.003
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