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Rationalizing the Formation of Activity Cliffs in Different Compound Data Sets

[Image: see text] Activity cliffs are formed by structurally analogous compounds with large potency variations and are highly relevant for the exploration of discontinuous structure–activity relationships and compound optimization. So far, activity cliffs have mostly been studied on a case-by-case b...

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Bibliografiske detaljer
Udgivet i:ACS Omega
Main Authors: Hu, Huabin, Stumpfe, Dagmar, Bajorath, Jürgen
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6644420/
https://ncbi.nlm.nih.gov/pubmed/31458921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01188
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