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Spermidine strongly increases the fidelity of Escherichia coli CRISPR Cas1–Cas2 integrase
Site-selective CRISPR array expansion at the origin of bacterial adaptive immunity relies on recognition of sequence-dependent DNA structures by the conserved Cas1–Cas2 integrase. Off-target integration of a new spacer sequence outside canonical CRISPR arrays has been described in vitro. However, th...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6643042/ https://ncbi.nlm.nih.gov/pubmed/31171718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007619 |
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