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DNA binding specificities of Escherichia coli Cas1–Cas2 integrase drive its recruitment at the CRISPR locus

Prokaryotic adaptive immunity relies on the capture of fragments of invader DNA (protospacers) followed by their recombination at a dedicated acceptor DNA locus. This integrative mechanism, called adaptation, needs both Cas1 and Cas2 proteins. Here, we studied in vitro the binding of an Escherichia...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Moch, Clara, Fromant, Michel, Blanquet, Sylvain, Plateau, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389526/
https://ncbi.nlm.nih.gov/pubmed/28034956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1309
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