Epigenetic programming underpins B cell dysfunction in human SLE

Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular pathogenic B cells derived from newly activated naïve cells. Although these cells express distinct markers, their epigenetic architecture and how it contributes to SLE remains poorly understood. To address this,...

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Vydáno v:Nat Immunol
Hlavní autoři: Scharer, Christopher D., Blalock, Emily L., Mi, Tian, Barwick, Benjamin G., Jenks, Scott A., Deguchi, Tsuneo, Cashman, Kevin S., Neary, Bridget E., Patterson, Dillon G., Hicks, Sakeenah L., Khosroshahi, Arezou, Lee, F. Eun-Hyung, Wei, Chungwen, Sanz, Iñaki, Boss, Jeremy M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642679/
https://ncbi.nlm.nih.gov/pubmed/31263277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0419-9
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