Epigenetic programming underpins B cell dysfunction in human SLE

Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular pathogenic B cells derived from newly activated naïve cells. Although these cells express distinct markers, their epigenetic architecture and how it contributes to SLE remains poorly understood. To address this,...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Scharer, Christopher D., Blalock, Emily L., Mi, Tian, Barwick, Benjamin G., Jenks, Scott A., Deguchi, Tsuneo, Cashman, Kevin S., Neary, Bridget E., Patterson, Dillon G., Hicks, Sakeenah L., Khosroshahi, Arezou, Lee, F. Eun-Hyung, Wei, Chungwen, Sanz, Iñaki, Boss, Jeremy M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642679/
https://ncbi.nlm.nih.gov/pubmed/31263277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0419-9
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