A20 and ABIN1 suppression of a keratinocyte inflammatory program with a shared single cell expression signature in diverse human rashes

Genetic variation in the NFκB inhibitors, ABIN1 and A20, increase risk for psoriasis. While critical for hematopoietic immune cell function, these genes are believed to additionally inhibit psoriasis by dampening inflammatory signaling in keratinocytes. We dissected ABIN1 and A20’s regulatory role i...

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Pubblicato in:J Invest Dermatol
Autori principali: Harirchian, Paymann, Lee, Jerry, Hilz, Stephanie, Sedgewick, Andrew J, White, Bethany E Perez, Kesling, Michael J., Mully, Thaddeus, Golovato, Justin, Gray, Matthew, Mauro, Theodora M, Purdom, Elizabeth, Kim, Esther A., Sbitany, Hani, Bhutani, Tina, Vaske, Charles J, Benz, Stephen C, Cho, Raymond J, Cheng, Jeffrey B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642632/
https://ncbi.nlm.nih.gov/pubmed/30543901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2018.10.046
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