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Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments
BACKGROUND: Innate immune cells such as macrophages are abundantly present within malignant ascites, where they share the microenvironment with ovarian cancer stem cells (CSC). METHODS: To mimic this malignant ascites microenvironment, we created a hanging-drop hetero-spheroid model to bring CSCs an...
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| Publicado no: | J Immunother Cancer |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6642605/ https://ncbi.nlm.nih.gov/pubmed/31324218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0666-1 |
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