FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding

BACKGROUND: The transcription factor Nrf2 is a master regulator of antioxidant response. While Nrf2 activation may counter increasing oxidative stress in aging, its activation in cancer can promote cancer progression and metastasis, and confer resistance to chemotherapy and radiotherapy. Thus, Nrf2...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EBioMedicine
Egile Nagusiak: Cheng, Kai-Chun, Lin, Ruey-Jen, Cheng, Jing-Yan, Wang, Sheng-Hung, Yu, Jyh-Cherng, Wu, Jen-Chine, Liang, Yuh-Jin, Hsu, Huan-Ming, Yu, John, Yu, Alice L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2019
Gaiak:
Research paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642435/
https://ncbi.nlm.nih.gov/pubmed/31262713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.06.022
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