Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer

BACKGROUND: The neddylation pathway is overactivated in human cancers. Inhibition of neddylation pathway has emerged as an attractive anticancer strategy. The mechanisms underlying neddylation overactivation in cancer remain elusive. MLN4924/Pevonedistat, a first-in-class NEDD8-activating enzyme (NA...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Li, Lihui, Kang, Jihui, Zhang, Wenjuan, Cai, Lili, Wang, Shiwen, Liang, Yupei, Jiang, Yanyu, Liu, Xiaojun, Zhang, Yunjing, Ruan, Hongfeng, Chen, Guoan, Wang, Mingsong, Jia, Lijun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
Soggetti:
Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642072/
https://ncbi.nlm.nih.gov/pubmed/31208947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.06.005
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