Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation

Cardiolipin (CL) is a unique phospholipid localized almost exclusively within the mitochondrial membranes where it is synthesized. Newly synthesized CL undergoes acyl remodeling to produce CL species enriched with unsaturated acyl groups. Cld1 is the only identified CL-specific phospholipase in yeas...

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Publicado no:Biochim Biophys Acta Mol Cell Biol Lipids
Main Authors: Lou, Wenjia, Ting, Hsiu-Chi, Reynolds, Christian A., Tyurina, Yulia Y., Tyurin, Vladimir A., Li, Yiran, Ji, Jiajia, Yu, Wenxi, Liang, Zhuqing, Stoyanovsky, Detcho A., Anthonymuthu, Tamil S., Frasso, Michael A., Wipf, Peter, Greenberger, Joel S., Bayir, Hülya, Kagan, Valerian E., Greenberg, Miriam L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6641546/
https://ncbi.nlm.nih.gov/pubmed/29935382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2018.06.016
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