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Druggability assessment of mammalian Per–Arnt–Sim [PAS] domains using computational approaches

Per–Arnt–Sim (PAS) domains are key regions that occur in different regulatory proteins from all kingdoms of life. PAS domains show a remarkably conserved structural scaffold, despite a highly variable primary sequence. In this study we have attempted to address some of the gaps in knowledge regardin...

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Bibliografische gegevens
Gepubliceerd in:Medchemcomm
Hoofdauteurs: de Souza, João V., Reznikov, Sylvia, Zhu, Ruidi, Bronowska, Agnieszka K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Royal Society of Chemistry 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640724/
https://ncbi.nlm.nih.gov/pubmed/31391885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00148d
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