Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning

CD117 (c-Kit) is a tyrosine kinase receptor that is overexpressed in multiple dog tumors. There is 100% homology between the juxtamembrane domain of human and canine CD117, and many cancer-causing mutations occur in this region in both species. Thus, CD117 is an important target for cancer treatment...

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Detalhes bibliográficos
Publicado no:Antibodies (Basel)
Main Authors: Alfaleh, Mohamed A., Arora, Neetika, Yeh, Michael, de Bakker, Christopher J., Howard, Christopher B., Macpherson, Philip, Allavena, Rachel E., Chen, Xiaoli, Harkness, Linda, Mahler, Stephen M., Jones, Martina L.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640692/
https://ncbi.nlm.nih.gov/pubmed/31544821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib8010015
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