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Subgroup-specific dose finding in phase I clinical trials based on time to toxicity allowing adaptive subgroup combination
A Bayesian design is presented that does precision dose-finding based on time to toxicity in a phase I clinical trial with two or more patient subgroups. The design, called Sub-TITE, makes sequentially adaptive subgroup-specific decisions while possibly combining subgroups that have similar estimate...
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| Published in: | Pharm Stat |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6640643/ https://ncbi.nlm.nih.gov/pubmed/30112806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pst.1891 |
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