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Inhibition of Protein Interactions: Co-Crystalized Protein-Protein Interfaces are Nearly as Good as Holo Proteins in Rigid-Body Ligand Docking

Modulating protein interaction pathways may lead to the cure of many diseases. Known protein-protein inhibitors bind to large pockets on the protein-protein interface. Such large pockets are detected also in the protein-protein complexes without known inhibitors, making such complexes potentially dr...

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Detalhes bibliográficos
Publicado no:J Comput Aided Mol Des
Main Authors: Belkin, Saveliy, Kundrotas, Petras J., Vakser, Ilya A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640133/
https://ncbi.nlm.nih.gov/pubmed/30003468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-018-0124-z
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