Cholesterol Binding to the Transmembrane Region of a Group 2 Hemagglutinin (HA) of Influenza Virus Is Essential for Virus Replication, Affecting both Virus Assembly and HA Fusion Activity

Hemagglutinin (HA) of influenza virus is incorporated into cholesterol-enriched nanodomains of the plasma membrane. Phylogenetic group 2 HAs contain the conserved cholesterol consensus motif (CCM) YKLW in the transmembrane region. We previously reported that mutations in the CCM retarded intracellul...

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Vydáno v:J Virol
Hlavní autoři: Hu, Bodan, Höfer, Chris Tina, Thiele, Christoph, Veit, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Structure and Assembly
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639284/
https://ncbi.nlm.nih.gov/pubmed/31118253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00555-19
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