The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline

The biological roles of nucleic acid methylation, other than at the C5-position of cytosines in CpG dinucleotides, are still not well understood. Here, we report genetic evidence for a critical role for the putative DNA demethylase NMAD-1 in regulating meiosis in C. elegans. nmad-1 mutants have redu...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Wang, Simon Yuan, Mao, Hui, Shibuya, Hiroki, Uzawa, Satoru, O’Brown, Zach Klapholz, Wesenberg, Sage, Shin, Nara, Saito, Takamune T., Gao, Jinmin, Meyer, Barbara J., Colaiácovo, Monica P., Greer, Eric Lieberman
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6638966/
https://ncbi.nlm.nih.gov/pubmed/31283754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008252
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