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Quick assessment for systematic test statistic inflation/deflation due to null model misspecifications in genome-wide environment interaction studies

Gene-environment (GxE) interaction is one potential explanation for the missing heritability problem. A popular approach to genome-wide environment interaction studies (GWEIS) is based on regression models involving interactions between genetic variants and environment variables. Unfortunately, GWEI...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ueki, Masao, Fujii, Masahiro, Tamiya, Gen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6638962/
https://ncbi.nlm.nih.gov/pubmed/31318927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219825
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