Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

The lack of new antibiotics is among the most critical challenges facing medicine. The problem is particularly acute for Gram-negative bacteria. A novel antibiotic strategy is to target bacterial nutrition and metabolism. The metal gallium can disrupt bacterial iron metabolism as gallium can be take...

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Publicat a:Sci Transl Med
Autors principals: Goss, Christopher H., Kaneko, Yukihiro, Khuu, Lisa, Anderson, Gail D., Ravishankar, Sumedha, Aitken, Moira L., Lechtzin, Noah, Zhou, Guolin, Czyz, Daniel, McLean, Kathryn, Olakanmi, Oyebode, Shuman, Howard A., Teresi, Mary, Wilhelm, Ellen, Caldwell, Ellen, Salipante, Stephen J., Hornick, Douglas B., Siehnel, Richard J., Becker, Lev, Britigan, Bradley E., Singh, Pradeep K.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637966/
https://ncbi.nlm.nih.gov/pubmed/30257953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aat7520
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