Gallium Disrupts Iron Uptake by Intracellular and Extracellular Francisella Strains and Exhibits Therapeutic Efficacy in a Murine Pulmonary Infection Model

Francisella tularensis requires iron (Fe) for growth, but the biologic sources of Fe for this organism are largely unknown. We found that Francisella sp. growing in broth culture or within human macrophages can acquire Fe from the two major host Fe-binding proteins, lactoferrin (Lf) and transferrin...

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Bibliographic Details
Main Authors: Olakanmi, Oyebode, Gunn, John S., Su, Shengchang, Soni, Shilpa, Hassett, Daniel J., Britigan, Bradley E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798485/
https://ncbi.nlm.nih.gov/pubmed/19917753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00655-09
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