Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

BACKGROUND: Whole-genome sequencing (WGS) is a powerful method for revealing the diversity and complexity of the somatic mutation burden of tumours. Here, we investigated the utility of tumour and matched germline WGS for understanding aetiology and treatment opportunities for high-risk individuals...

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Опубликовано в: :Ann Oncol
Главные авторы: Nones, K, Johnson, J, Newell, F, Patch, A M, Thorne, H, Kazakoff, S H, de Luca, X M, Parsons, M T, Ferguson, K, Reid, L E, McCart Reed, A E, Srihari, S, Lakis, V, Davidson, A L, Mukhopadhyay, P, Holmes, O, Xu, Q, Wood, S, Leonard, C, Beesley, J, Harris, J M, Barnes, D, Degasperi, A, Ragan, M A, Spurdle, A B, Khanna, K K, Lakhani, S R, Pearson, J V, Nik-Zainal, S, Chenevix-Trench, G, Waddell, N, Simpson, P T
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637375/
https://ncbi.nlm.nih.gov/pubmed/31090900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdz132
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