Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

BACKGROUND: Whole-genome sequencing (WGS) is a powerful method for revealing the diversity and complexity of the somatic mutation burden of tumours. Here, we investigated the utility of tumour and matched germline WGS for understanding aetiology and treatment opportunities for high-risk individuals...

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Detalhes bibliográficos
Publicado no:Ann Oncol
Main Authors: Nones, K, Johnson, J, Newell, F, Patch, A M, Thorne, H, Kazakoff, S H, de Luca, X M, Parsons, M T, Ferguson, K, Reid, L E, McCart Reed, A E, Srihari, S, Lakis, V, Davidson, A L, Mukhopadhyay, P, Holmes, O, Xu, Q, Wood, S, Leonard, C, Beesley, J, Harris, J M, Barnes, D, Degasperi, A, Ragan, M A, Spurdle, A B, Khanna, K K, Lakhani, S R, Pearson, J V, Nik-Zainal, S, Chenevix-Trench, G, Waddell, N, Simpson, P T
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637375/
https://ncbi.nlm.nih.gov/pubmed/31090900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdz132
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