Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

BACKGROUND: Whole-genome sequencing (WGS) is a powerful method for revealing the diversity and complexity of the somatic mutation burden of tumours. Here, we investigated the utility of tumour and matched germline WGS for understanding aetiology and treatment opportunities for high-risk individuals...

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Vydáno v:Ann Oncol
Hlavní autoři: Nones, K, Johnson, J, Newell, F, Patch, A M, Thorne, H, Kazakoff, S H, de Luca, X M, Parsons, M T, Ferguson, K, Reid, L E, McCart Reed, A E, Srihari, S, Lakis, V, Davidson, A L, Mukhopadhyay, P, Holmes, O, Xu, Q, Wood, S, Leonard, C, Beesley, J, Harris, J M, Barnes, D, Degasperi, A, Ragan, M A, Spurdle, A B, Khanna, K K, Lakhani, S R, Pearson, J V, Nik-Zainal, S, Chenevix-Trench, G, Waddell, N, Simpson, P T
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637375/
https://ncbi.nlm.nih.gov/pubmed/31090900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdz132
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